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Medip Archive

The archive of journals published by Medip Academy.

Browse and search peer-reviewed research from Medip Academy's international medical journals, covering pharmacology, obstetrics and gynecology, pediatrics, community medicine and public health, clinical trials, dermatology, orthopaedics, otorhinolaryngology and more.

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Journals in Medip Archive

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Now showing 1 - 5 of 12

Recent Submissions

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    Item type:Publication,
    Current perspective of severe adverse events and compensation requirements in India
    (Medip Academy, 2014-08-01)
    Goyal, Shekhar
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    Kapoor, Akhil
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    Bhadu, Indra
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    Department of Clinical Operations, SIARAM Clinical Research Centre, Bikaner, Rajasthan, India
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    Department of Oncology, Acharya Tulsi Regional Cancer Treatment and Research Institute, Sardar Patel Medical College and AG of Hospitals, Bikaner, Rajasthan, India
    As per Drug Controller General of India (DCGI), there are clear cut compensation guidelines for clinical trial participants in case of death and injury after amendment in schedule Y (Rule 122DAB - Compensation in case of injury or death during clinical trial). The purpose of these guidelines is to provide Severe Adverse Event (SAE) compensation calculation as well as determination of the ratio of amount in clinical trial injury.
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    Item type:Publication,
    A randomised comparative study of dexmedetomidine and midazolam for sedation during awake fiberoptic intubation in laproscopic cholecystectomy patients
    (Medip Academy, 2015-05-16)
    Singh, Praneet
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    Punia, T. S.
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    Kaur, Balwinder
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    Ramachandriah, Pavan
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    Kaur, Jaspreet
    Background: Fiberoptic nasotracheal intubation is an effective method for the management of patients with difficult airways. An ideal sedation regimen would ensure patient’s comfort, attenuation of airway reflexes, patient’s co-ordination, haemodynamic stability and amnesia. It is critical for both the surgeon and the anesthesiologist to understand the physiologic consequences of laparoscopy and to work in cooperation to achieve a good surgical outcome.Methods: Patients were randomly allocated to midazolam (MDZ) group (group 1) and dexmedetomidine (DEX) group (group 2). DEX patients received dexmedetomidine 1μg/kg, followed by an infusion of dexmedetomidine 0.1μg/kg/hr titrated to 0.7μg/kg/hr to achieve RSS ≥2. MDZ subjects received IV midazolam 0.05mg/kg with additional doses given to achieve a RSS ≥ 2.Measurements: Pulse rate, systolic and diastolic blood pressures and SpO2 recorded during pre-oxygenation, one minute prior to introduction of fiberscope and then every minute for the following five minutes and  beginning one minute before endotracheal intubation and then every minute until the endotracheal tube was secured, patient’s tolerance assessed on 5 point fiberoptic intubation score during fiberscopy and endotracheal intubation, total comfort score values assessed during pre-oxygenation, fiberscopy and endotracheal intubation and patient’s response to 24 hour post op questionnaire assessment were measured.Results: DEX group patients were significantly more quiet and more harmonius during awake fiberoptic intubation (AFOI) than were the MDZ group patients. The DEX group patients were found to have a lower mean Heart Rate than the MDZ patients.Conclusions: Both dexmedetomidine and midazolam are effective for fibreoptic intubation. Dexmedetomidine allows better endurance, stable haemodynamic status and a patent airway.
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    Item type:Publication,
    The MESS: is it must?
    (Medip Academy, 2014-08-01)
    Ram, Ganesan G.
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    Rajappa, Srinivasan
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    Department of Orthopaedics, Sri Ramachandra Medical College, Porur, Chennai, Tamil Nadu, India
    Background: Massive lower extremity trauma presents an immediate and complex decision making challenge. Significant advancements have made in the field of reconstructive surgery over the past 30 years. Severely traumatised limbs which would have been treated by primary amputation 20 years ago are beginning to be saved. On the contrary, such extensive reconstructive procedures may not always produce the best of results in terms of functional outcomes. Thus the management of a severely crushed extremity presents a therapeutic dilemma as whether to amputate or to attempt salvage.Methods: All Prospective study of 40 patients with severe crush injury to the lower extremities treated in Sri Ramachandra Medical College, Chennai between June 2012 and June 2014. The inclusion criteria were grade IIIb and grade IIIc open fractures of the lower extremity with a Mangled extremity severity score (MESS) of 7 and above with minimum of 12 months follow up. All the fractures were classified according to the Gustilo and Anderson classification system and Mangled extremity severity score. Out of the 40 patients 18 of them had their limbs salvaged and 22 underwent primary amputation.  Results: The lowest MESS in this study was 7 and highest MESS was 12. The mean score in the limb salvage group was 8 and in the amputated group was 9.7. Complication rates in salvage group were higher. The mean SF score for amputated group for physical component summary was 40.15 and mental component summary was 44.30 while for limb salvage group score for physical component summary was 30.91 and mental component summary was 36.90.Conclusions: The MESS scheme provides excellent guidelines to the treating surgeon when faced with a dilemma of whether to attempt salvage or amputate a severely injured limb. The decision of whether to amputate or salvage an injured limb must be made very early in the course of treatment. This is because immediate amputation is most often viewed by the patient as a result of injury; whereas, delayed amputation is often considered as a failure of treatment.
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    Item type:Publication,
    Multi-arm clinical trials: the need of the hour
    (Medip Academy, 2014-08-01)
    Dharmshaktu, Ganesh Singh
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    Department of Orthopaedics, Government Medical College, Haldwani, Uttarakhand, India
    There has been an academic initiative as researchers propose that more and more attention and activity should be attributed to multi-arm clinical trials. In contrast to the conventional two-arm trials with one variable compared to the other, these multi-arm trials would be instrumental in getting more outcome comparing several things together. This will enable researchers to arrive at fruitful conclusions more likely and that too saving time and money.
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    Item type:Publication,
    Eating frequency and weight loss: results of 6 months follow up of a public health campaign at Aurangabad
    (Medip Academy, 2014-08-01)
    Dixit, J. V.
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    Associate Professor, Department of Preventive & Social Medicine, Government Medical College, Aurangabad-431001, Maharashtra, India
    Background: Obesity is a major health problem in developed as well as developing countries. The “carbo-insulin connection” theory was popularized by late Dr. Shrikant Jichkar from 1997 to 2004. He advocated the idea of eating only twice a day to lose weight and prevent obesity. The author tried this theory on himself from January to March 2013 and lost 8kg of weight and 2 inches from his belly! Since then the author is conducting lectures for lay people educating them about eating twice and losing weight. Author has addressed audiences in many cities and towns of Maharashtra. The present study provides the encouraging results of this public health campaign.Methods: This study was a self-controlled community trial. The tenure of the study was from 1st July 2013 to 30th June 2014. The subjects were enrolled in the study after taking their informed consent during the author’s lectures on weight loss arranged in various cities and towns of Maharashtra. The author got pretested questionnaires filled from the audience who attended his lectures on weight loss. The follow up was done on phone every fortnightly. Total 446 individuals participated in this campaign.Results: The weight loss and decrease in waist circumference in participants was as below: weight loss: average 1.5 kg in first month, 4.2 kg in 3 months and 6.8 kg in 6 months; inches loss: average 0.5 cm in 1st month, 1.5 cm in 3 months and 3.5 cm in 6 months. No side effects were observed.Conclusions: The weight loss activities have taken a form of exploitative business for many. Poor and ignorant people are being looted. This simple method of weight loss costs nothing, there is no requirement of a doctor and contrary to many other successful methods of weight loss, can be followed for a life time. Hence such a simple method should be advocated for all. There is a need to spread this message in the form of a public health campaign.